N-苯基哌嗪

化合物

N-苯基哌嗪是一種有機化合物,化學式為C10H14N2。它可由氯苯哌嗪叔丁醇鉀的存在下於二氧六環中反應得到,[2]也有文獻以溴苯為原料、氫氧化鈉為鹼進行反應。[3]它的哌嗪環一段的N-H還能繼續發生反應,如和2-氯-6-甲基吡啶在的存在下反應,得到1-(6-甲基吡啶-2-基)-4-苯基哌嗪。[4]

N-苯基哌嗪
Skeletal formula of phenylpiperazine
Ball-and-stick model of the phenylpiperazine molecule
IUPAC名
1-Phenylpiperazine
識別
CAS號 92-54-6  checkY
PubChem 7096
ChemSpider 6829
SMILES
 
  • c1cc(ccc1)N2CCNCC2
性質
化學式 C10H14N2
莫耳質量 162.23 g/mol g·mol⁻¹
外觀 無色至黃色液體
密度 1.028 g/cm3
熔點 18.8 °C(292 K)
沸點 287.2 °C(560 K)
溶解性 10 g(25 °C)[1]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考文獻

編輯
  1. ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-10]
  2. ^ Muthukumaran Nirmala, Gandhi Saranya, Periasamy Viswanathamurthi, Roberta Bertani, Paolo Sgarbossa, Jan Grzegorz Malecki. Organonickel complexes encumbering bis-imidazolylidene carbene ligands: Synthesis, X-ray structure and catalytic insights on Buchwald-Hartwig amination reactions. Journal of Organometallic Chemistry. 2017-03, 831: 1–10 [2021-04-10]. doi:10.1016/j.jorganchem.2016.12.029. (原始內容存檔於2020-02-16) (英語). 
  3. ^ Atul Kumar, Ajay Kumar Bishnoi. Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water. RSC Advances. 2015, 5 (26): 20516–20520 [2021-04-10]. ISSN 2046-2069. doi:10.1039/C4RA15267K (英語). 
  4. ^ Fei-Dong Huang, Chang Xu, Dong-Dong Lu, Dong-Sheng Shen, Tian Li, Feng-Shou Liu. Pd-PEPPSI-IPent An Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions. The Journal of Organic Chemistry. 2018-08-17, 83 (16): 9144–9155 [2021-04-10]. ISSN 0022-3263. doi:10.1021/acs.joc.8b01205. (原始內容存檔於2021-12-15) (英語).