血小板內皮細胞黏附分子

PECAM1
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	2KY5、5C14
識別號
別名	PECAM1；, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1
外部ID	OMIM：173445 MGI：97537 HomoloGene：47925 GeneCards：PECAM1
基因位置（人類）
染色體	17號染色體
終止	64,413,776 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	106,641,454 bp
RNA表現模式
	; ; ; ;
	查閱更多表現資料
基因本體
分子功能	• 血漿蛋白結合; • protein homodimerization activity;
細胞組分	• integral component of membrane; • platelet alpha granule membrane; • 脂筏模型; • 細胞連接; • 細胞膜; • 外排體; • 膜; • 細胞外空間; • secretory granule membrane; • 細胞質; • external side of plasma membrane; • smooth muscle contractile fiber; • cell-cell contact zone; • cell periphery;
生物學過程	• diapedesis; • glomerular endothelium development; • platelet degranulation; • 細胞粘附; • extracellular matrix organization; • cell recognition; • leukocyte migration; • 訊息傳遞; • 吞噬作用; • neutrophil degranulation; • leukocyte cell-cell adhesion; • neutrophil extravasation; • cell-cell adhesion via plasma-membrane adhesion molecules; • 血管新生; • endothelial cell morphogenesis; • homophilic cell adhesion via plasma membrane adhesion molecules; • Rho protein signal transduction; • regulation of cell migration; • monocyte extravasation; • 傷口癒合; • positive regulation of tyrosine phosphorylation of STAT protein; • endothelial cell migration; • endothelial cell-matrix adhesion;
	Sources:Amigo / QuickGO
直系同源
	5175
	18613
	ENSG00000261371
	ENSMUSG00000020717
	P16284
	Q08481
	NM_000442
	NM_001032378; NM_008816; NM_001305157; NM_001305158
	NP_000433
	NP_001027550; NP_001292086; NP_001292087; NP_032842
	維基資料
檢視/編輯人類	檢視/編輯小鼠

血小板內皮細胞黏附分子（英語：Platelet endothelial cell adhesion molecule，縮寫PECAM-1，也稱為CD31，cluster of differentiation 31，分化簇31）是一種細胞表面蛋白質，由人類17號染色體上的基因 PECAM1 編碼，是內皮細胞與CFU-GM細胞的主要標誌物^[5]^[6]^[7]。

參考文獻編輯

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000261371 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000020717 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. March 1990, 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. PMID 1690453. doi:10.1126/science.1690453.
^ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ. The human PECAM1 gene maps to 17q23. Genomics. June 1996, 34 (2): 229–232. PMID 8661055. doi:10.1006/geno.1996.0272.
^ Xie Y, Muller WA. Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1. Genomics. October 1996, 37 (2): 226–228. PMID 8921400. doi:10.1006/geno.1996.0546.

外部連結編輯

Human CD Antigen Chart (eBioscience)
Mouse CD Antigen Chart (eBioscience)
Human PECAM1 genome location and PECAM1 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.
PDB中UniProt可用的所有結構資訊之概述：P16284 (Platelet endothelial cell adhesion molecule) 在PDBe-KB（英語：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000261371 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000020717 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1690453-5] Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. March 1990, 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. PMID 1690453. doi:10.1126/science.1690453.

[pmid8661055-6] Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ. The human PECAM1 gene maps to 17q23. Genomics. June 1996, 34 (2): 229–232. PMID 8661055. doi:10.1006/geno.1996.0272.

[pmid8921400-7] Xie Y, Muller WA. Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1. Genomics. October 1996, 37 (2): 226–228. PMID 8921400. doi:10.1006/geno.1996.0546.

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血小板內皮細胞黏附分子

參考文獻 編輯

外部連結 編輯

參考文獻編輯

外部連結編輯