5-HT4受體

位於5號人類染色體的基因

5-HT4受体5-羟色胺受体4(英语:5-Hydroxytryptamine receptor 4)是在人类上由HTR4基因编码的蛋白质[6][7]

5-HT4受体
识别号
别名HTR4;, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
外部IDOMIM602164 MGI109246 HomoloGene20243 GeneCardsHTR4
为以下药物的标靶
维拉佐酮、​血清素、​5-甲氧基色胺、​α-methyl-5-HT、​莫沙必利、​伦扎必利、​扎考必利、​普芦卡必利、​RS 67333、​GR-113808、​哌波色罗、​SB 204070、​levosulpiride、​齐美定、​capeserod、​relenopride、​td-8954、​metoclopramide hydrochloride hydrate[1]
基因位置(人类
5号染色体
染色体5号染色体[2]
5号染色体
5-HT4受体的基因位置
5-HT4受体的基因位置
基因座5q32起始148,451,032 bp[2]
终止148,677,235 bp[2]
RNA表达模式




查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_008313
​NM_001364956
​NM_001364957
​NM_001364958
​NM_001364959

蛋白序列

NP_032339
​NP_001351885
​NP_001351886
​NP_001351887
​NP_001351888

基因位置​(UCSC)Chr 5: 148.45 – 148.68 MbChr 18: 62.46 – 62.63 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

配体

编辑

激动剂

编辑

拮抗剂

编辑
  • Piboserod英语Piboserod
  • GR-113,808英语GR-113,808 (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)[9]
  • GR-125,487
  • RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)
  • SB-203,186
  • SB-204,070英语SB-204,070
  • ([Methoxy-11C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate[10]
  • 洋甘菊(酒精萃取)[11]

参见

编辑

参考资料

编辑
  1. ^ 對5-hydroxytryptamine receptor 4起作用的藥物;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000164270 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026322 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S. Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization. Cytogenetics and Cell Genetics. December 1997, 78 (2): 133–4. PMID 9371406. doi:10.1159/000134646. 
  7. ^ Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X. 
  8. ^ Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia. Pain. March 2011, 152 (3): 687–97. PMID 21239110. doi:10.1016/j.pain.2010.12.020. 
  9. ^ Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. British Journal of Pharmacology. January 1994, 111 (1): 332–8. PMC 1910004 . PMID 8012715. doi:10.1111/j.1476-5381.1994.tb14064.x. 
  10. ^ Xu R, Hong J, Morse CL, Pike VW. Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. Journal of Medicinal Chemistry. October 2010, 53 (19): 7035–47. PMC 2951497 . PMID 20812727. doi:10.1021/jm100668r. 
  11. ^ Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors. Phytomedicine: 51–5. PMID 16973340. doi:10.1016/j.phymed.2006.03.012. 

深入阅读

编辑

外部链接

编辑
  • 5-HT4. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. (原始内容存档于2016-06-05). 


5-HT4受体引用了美国国家医学图书馆提供的数据,这些数据属于公共领域


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