模板:已上市安非他命药物中的安非他命物质组成

已上市安非他命药物中的安非他命物质组成 
药物 化学式 分子量[I] amphetamine base
[II]
amphetamine base
in equal doses
doses with
equal base content[III]
(g/mol) (percent) (30 mg dose)
total base total dextro- levo- dextro- levo-
dextroamphetamine sulfate[2][3] (C9H13N)2•H2SO4
368.49
270.41
73.38%
73.38%
22.0 mg
30.0 mg
amphetamine sulfate[4] (C9H13N)2•H2SO4
368.49
270.41
73.38%
36.69%
36.69%
11.0 mg
11.0 mg
30.0 mg
Adderall
62.57%
47.49%
15.08%
14.2 mg
4.5 mg
35.2 mg
25% dextroamphetamine sulfate[2][3] (C9H13N)2•H2SO4
368.49
270.41
73.38%
73.38%
25% amphetamine sulfate[4] (C9H13N)2•H2SO4
368.49
270.41
73.38%
36.69%
36.69%
25% dextroamphetamine saccharate[5] (C9H13N)2•C6H10O8
480.55
270.41
56.27%
56.27%
25% amphetamine aspartate monohydrate[6] (C9H13N)•C4H7NO4•H2O
286.32
135.21
47.22%
23.61%
23.61%
lisdexamfetamine dimesylate[7] C15H25N3O•(CH4O3S)2
455.49
135.21
29.68%
29.68%
8.9 mg
74.2 mg
amphetamine base suspension[IV][8] C9H13N
135.21
135.21
100%
76.19%
23.81%
22.9 mg
7.1 mg
22.0 mg

参考资料

  1. ^ Molecular Weight Calculator. Lenntech. [19 August 2015]. 
  2. ^ 2.0 2.1 Dextroamphetamine Sulfate USP. Mallinckrodt Pharmaceuticals. March 2014 [19 August 2015]. 
  3. ^ 3.0 3.1 D-amphetamine sulfate. Tocris. 2015 [19 August 2015]. 
  4. ^ 4.0 4.1 Amphetamine Sulfate USP. Mallinckrodt Pharmaceuticals. March 2014 [19 August 2015]. 
  5. ^ Dextroamphetamine Saccharate. Mallinckrodt Pharmaceuticals. March 2014 [19 August 2015]. 
  6. ^ Amphetamine Aspartate. Mallinckrodt Pharmaceuticals. March 2014 [19 August 2015]. 
  7. ^ Vyvanse Prescribing Information (PDF). United States Food and Drug Administration. Shire US Inc.: 17–21. May 2017 [10 July 2017]. 
  8. ^ 8.0 8.1 8.2 Dyanavel XR Prescribing Information (PDF). United States Food and Drug Administration. Tris Pharma, Inc.: 1–14. May 2017 [4 August 2017]. DYANAVEL XR contains d-amphetamine and l-amphetamine in a ratio of 3.2 to 1 ...
    DOSAGE FORMS AND STRENGTHS
    Extended-release oral suspension contains 2.5 mg amphetamine base per mL.
     
  1. ^ For uniformity, molecular masses were calculated using the Lenntech Molecular Weight Calculator[1] and were within 0.01g/mol of published pharmaceutical values.
  2. ^ Amphetamine base percentage=molecular massbase / molecular masstotal. Amphetamine base percentage for Adderall = sum of component percentages / 4.
  3. ^ (1 / amphetamine base percentage) × scaling factor = (molecular masstotal / molecular massbase) × scaling factor. The values in this column were scaled to a 30 mg dose of dextroamphetamine sulfate. Due to pharmacological differences between these medications (e.g., differences in the release, absorption, conversion, concentration, differing effects of enantiomers, half-life, etc.), the listed values should not be considered equipotent doses.
  4. ^ This product (Dyanavel XR) is an oral suspension (i.e., a drug that is suspended in a liquid and taken by mouth) that contains 2.5 mg/mL of amphetamine base.[8] The product uses an ion exchange resin to achieve extended release of the amphetamine base.[8]