丁烯沙林CRS)是G系列內一種劇毒的有機磷神經性毒劑[1]CRS像其他神經性毒劑一樣,會不可逆轉地抑制乙酰膽鹼酯酶。然而,因為所抑制的酶很快老化,所以它不能被活化劑活化。[2][3]

丁烯沙林
IUPAC名
(2E)-But-2-en-1-yl methylphosphonofluoridate
別名 CRS
2-丁烯基-P-甲基膦酰氟
識別
CAS號 138780-00-4(2E checkY
PubChem 6438716
ChemSpider 4943171
SMILES
 
  • C/C=C/COP(=O)(C)F
性質
化學式 C5H10FO2P
摩爾質量 152.1 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參見

編輯

參考文獻

編輯
  1. ^ Worek, Franz; Wille, Timo; Koller, Marianne; Thiermann, Horst. Toxicology of organophosphorus compounds in view of an increasing terrorist threat. Archives of Toxicology. 27 June 2016, 90 (9): 2131–2145. PMID 27349770. S2CID 15724842. doi:10.1007/s00204-016-1772-1. 
  2. ^ Busker, R.W.; Zijlstra, J.J.; van der Wiel, H.J.; Melchers, B.P.C.; van Helden, H.P.M. Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the rat. Toxicology. January 1991, 69 (3): 331–344. PMID 1658986. doi:10.1016/0300-483x(91)90191-3. 
  3. ^ Soukup, O.; Jun, D.; Tobin, G.; Kuca, K. The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Archives of Toxicology. 21 November 2012, 87 (4): 711–719. PMID 23179755. S2CID 18252681. doi:10.1007/s00204-012-0977-1.