SIB-1757

**SIB-1757**
識別資訊
	IUPAC命名法 6-methyl-2-(phenylazo)-3-pyridinol; ;
CAS號	31993-01-8
PubChem CID	6849066;
ChemSpider	10654582;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID00425754 ;
ECHA InfoCard	100.164.315
化學資訊
化學式	C12H11N3O
摩爾質量	213.24 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES Oc1ccc(C)nc1\N=N\c2ccccc2;
	InChI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+; Key:LOCPVWIREQIGNQ-CCEZHUSRSA-N;

SIB-1757是一種有機化合物，分子式C₁₂H₁₁N₃O，帶有偶氮基團，可作為代謝型穀氨酸受體亞型mGluR₅的受體拮抗劑^[1]，在動物實驗中存在抗痛覺過敏作用^[2]。

參考文獻

^ Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. The Journal of Pharmacology and Experimental Therapeutics. July 1999, 290 (1): 170–81. PMID 10381773.
^ Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. October 2000, 292 (2): 115–8. PMID 10998562. doi:10.1016/S0304-3940(00)01458-0.

識別資訊

IUPAC命名法 6-methyl-2-(phenylazo)-3-pyridinol
CAS號	31993-01-8 ^Y
PubChem CID	6849066
ChemSpider	10654582
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID00425754
ECHA InfoCard	100.164.315
化學資訊
化學式	C₁₂H₁₁N₃O
摩爾質量	213.24 g·mol⁻¹
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES Oc1ccc(C)nc1\N=N\c2ccccc2
InChI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+ Key:LOCPVWIREQIGNQ-CCEZHUSRSA-N