SIBLING蛋白是一種非膠原蛋白,是牙本質細胞外基質的組成部分。其英文部分「SIBLING」為小整聯N-連接糖蛋白(small integrin-binding ligand, N-linked glycoprotein)的縮寫。有證據表明SIBLING蛋白在這些組織的礦化中起關鍵作用。[1]

下列蛋白質屬於SIBLING蛋白:[1][2]

  1. 骨橋蛋白 Osteopontin (OPN) 或分泌磷蛋白1 Secreted phosphoprotein 1 (SPP1);
  2. 骨涎蛋白 bone sialoprotein (BSP);
  3. 牙本質基質蛋白1 Dentin matrix protein 1 (DMP1);
  4. 牙本質唾液酸磷酸蛋白 Dentin sialophosphoprotein (DSPP);
  5. 基質細胞外磷酸糖蛋白 Matrix extracellular phosphoglycoprotein (MEPE)。

編碼SIBLING家族蛋白的基因位於人類染色體4q21-23上。[3]

參考文獻

編輯
  1. ^ 1.0 1.1 Qin, C.; Baba, O.; Butler, W.T. (2004). "Post-Translational Modifications of Sibling Proteins and Their Roles in Osteogenesis and Dentinogenesis". Critical Reviews in Oral Biology & Medicine. 15 (3): 126–36. doi:10.1177/154411130401500302. PMID 15187031.
  2. ^ Chaplet, M; De Leval, L; Waltregny, D; Detry, C; Fornaciari, G; Bevilacqua, G; Fisher, LW; Castronovo, V; Bellahcène, A (2003). "Dentin Matrix Protein 1 is Expressed in Human Lung Cancer". Journal of Bone and Mineral Research. 18 (8): 1506–12. doi:10.1359/jbmr.2003.18.8.1506. PMID 12929940. INIST:15005341.
  3. ^ Rittling, Susan R.; Denhardt, David T. (1999). "Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice". Nephron Experimental Nephrology. 7 (2): 103–13. doi:10.1159/000020591. PMID 10213864.