雷莫司琼

化合物

雷莫司琼INN:ramosetron),或译拉莫司琼,是一种血清素5-HT3受体拮抗剂,用于治疗恶心和呕吐。[1]雷莫司琼还适用于治疗以腹泻为主的肠易激综合征。[2]

雷莫司琼
臨床資料
AHFS/Drugs.com国际药品名称
给药途径口服ODT英语Orally disintegrating tablet)、静脉注射
ATC碼
  • 未分配
藥物動力學數據
生物半衰期5.8小时
识别信息
  • (1-Methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]methanone
CAS号132036-88-5  checkY
132907-72-3  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C17H17N3O
摩尔质量279.34 g·mol−1
3D模型(JSmol英语JSmol
  • CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4
  • InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1 ☒N
  • Key:NTHPAPBPFQJABD-LLVKDONJSA-N ☒N

参考资料

编辑
  1. ^ Fujii Y, Saitoh Y, Tanaka H, Toyooka H. Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery. Anesth. Analg. February 2000, 90 (2): 472–5. PMID 10648342. doi:10.1097/00000539-200002000-00043 . 
  2. ^ Grover, Madhusudan; Camilleri, Michael. Ramosetron in Irritable Bowel Syndrome with Diarrhea: New hope or the same old story?. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2014-06, 12 (6): 960–962 [2024-04-02]. ISSN 1542-3565. PMC 4032610 . PMID 24393804. doi:10.1016/j.cgh.2013.12.025. (原始内容存档于2024-04-02).