叔丁哌苯(英語:Budipine,也译为布地平)商品名Parkinsan,分子式C21H27N,是一种帕金森氏症治疗药物[2][3],其作用机制尚未解明[4]

叔丁哌苯
臨床資料
AHFS/Drugs.com国际药品名称
ATC碼
识别信息
  • 1-tert-butyl-4,4-diphenylpiperidine[1]
CAS号57982-78-2  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.055.494 編輯維基數據鏈接
化学信息
化学式C21H27N
摩尔质量293.45 g·mol−1
3D模型(JSmol英语JSmol
  • c1(ccccc1)C3(c2ccccc2)CCN(C(C)(C)C)CC3
  • InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3 checkY
  • Key:QIHLUZAFSSMXHQ-UHFFFAOYSA-N checkY
合成方式[5]

参考文献

编辑
  1. ^ Sweetman SC (编). Martindale: The Complete Drug Reference. 35th. London: Pharmaceutical Press. 2007. ISBN 978-0-85369-687-2. 
  2. ^ Przuntek H, Müller T. Clinical efficacy of budipine in Parkinson's disease. Journal of Neural Transmission. Supplementum. 1999, 56: 75–82. ISBN 978-3-211-83275-2. PMID 10370903. doi:10.1007/978-3-7091-6360-3_3. 
  3. ^ Budipine. AdisInsight. Springer Nature Switzerland AG. [2023-08-21]. (原始内容存档于2023-05-07). 
  4. ^ Reichmann H. Budipine in Parkinson's tremor. Journal of the Neurological Sciences. October 2006, 248 (1–2): 53–55. PMID 16784759. S2CID 21540225. doi:10.1016/j.jns.2006.05.039. 
  5. ^ Schaefer H, Hackmack G, Eistetter K, Krüger U, Menge HG, Klosa J. [Synthesis, physical-chemical properties and pharmacologically-oriented screening studies on budipine and related 4,4-diphenylpiperidines]. Arzneimittel-Forschung. 1984, 34 (3): 233–240. PMID 6539602 (德语). 

外部链接

编辑