Lin-4
lin-4是最早发现的microRNA[1]，1993年发现于模式生物秀麗隱桿線蟲的基因组中[2]，转录形成70碱基的前体后由Dicer酶切割形成21碱基的产物[3]。
| lin-4 microRNA precursor | |
|---|---|
| |
| 预测的lin-4二级结构和保守序列 | |
| 识别符 | |
| 代号 | lin-4 |
| Rfam | RF00052 |
| miRBase | MI0000002 |
| miRBase | MIPF0000303 |
| 其他数据 | |
| RNA类型 | Gene; miRNA |
| 域 | Eukaryota |
参考文献 编辑
- ^ Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.. Cell. 1993, 75 (5): 843–854. PMID 8252621. doi:10.1016/0092-8674(93)90529-Y
.
- ^ Ambros, V. microRNAs: tiny regulators with great potential. Cell. 2001, 107 (7): 823–826. PMID 11779458. doi:10.1016/S0092-8674(01)00616-X .
- ^ Rougvie, AE. Control of developmental timing in animals. Nat Rev Genet. 2001, 2 (9): 690–701. PMID 11533718. doi:10.1038/35088566.
